Peripheral Nerve Allografting - Why and How
S.C. Bădoiu, I. Lascăr, D.M. EnescuGeneral reports, no. 5, 2014
The authors briefly present the methods of reconstruction of peripheral nerve gaps. Of these methods, the reconstruction with nerve allografts is reviewed mainly in what concerns theways to achieve host tolerance for the allograft. The authors underline the fact that, for the recipient it is better to suppressthe graft antigenicity than to suppress the host immuneresponse. Further, the authors present the most important methods to denaturate a nerve allograft in order to make it nonantigenicand insist upon developing methods that can be usedin human beings. The authors conclude that reconstruction of nerve defects with peripheral nerve allografts is a veryrewarding method that should be extended in clinical practice.
